Neurobiology of Disease Rebalance of Striatal NMDA/AMPA Receptor Ratio Underlies the Reduced Emergence of Dyskinesia During D2-Like Dopamine Agonist Treatment in Experimental Parkinson’s Disease
نویسندگان
چکیده
Vincenza Bagetta,1* Carmelo Sgobio,1* Valentina Pendolino,1 Giulia Del Papa,1 Alessandro Tozzi,1,2 Veronica Ghiglieri,1 Carmela Giampà,1 Elisa Zianni,3 Fabrizio Gardoni,3 Paolo Calabresi,1,2 and Barbara Picconi1 1Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, 00143 Rome, Italy, 2Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy, and 3Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy
منابع مشابه
A study on striatal local electrical potential changes in an animal model of Parkinson's disease
Parkinson’s disease (PD) is a neurodegenerative disorder that does not develop spontaneously in some animal species. PD can be induced experimentally in some laboratory animals including mouse, rat and horse. Globus pallidus (GP) and substantia nigra pars compacta (SNc) are damaged in patients with PD. The hallmark of PD is a progressive impaired control of movement, an alteration of autonomic ...
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The D3 dopamine (DA) receptor is a member of the D2-like DA receptor family. While the D2 receptor is abundant especially in motor-regions of the striatum, the D3 receptor shows a relative abundance in limbic regions and globus pallidus. This receptor is of current interest in neurology because of its potential involvement in psychiatric and motor complications in Parkinson’s disease and the po...
متن کاملA study on striatal local electrical potential changes in an animal model of Parkinson's disease
Parkinson’s disease (PD) is a neurodegenerative disorder that does not develop spontaneously in some animal species. PD can be induced experimentally in some laboratory animals including mouse, rat and horse. Globus pallidus (GP) and substantia nigra pars compacta (SNc) are damaged in patients with PD. The hallmark of PD is a progressive impaired control of movement, an alteration of autonomic ...
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The principal neurons of the striatum, GABAergic medium spiny neurons (MSNs), are interconnected by local recurrent axon collateral synapses. Although critical to many striatal models, it is not clear whether these connections are random or whether they preferentially link functionally related groups of MSNs. To address this issue, dual whole patch-clamp recordings were made from striatal MSNs ...
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